SML1497

Canrenone

≥97% (HPLC)

• Synonyme(s) : (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713
• Formule empirique (notation de Hill): C₂₂H₂₈O₃
• Numéro CAS: 976-71-6
• Poids moléculaire : 340.46
• Numéro MDL: MFCD00071735
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825921
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: powder
• Activité optique: [α]/D +17 to +24°, c = 1 in chloroform-d
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O
• InChI: 1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
• Clé InChI: UJVLDDZCTMKXJK-WNHSNXHDSA-N
• Informations sur le gène: human ... NR3C2(4306)

Description

Actions biochimiques/physiologiques

Canrenone is a mineralocorticoid (aldosterone) inhibitor.

Canrenone is a mineralocorticoid (aldosterone) inhibitor. Aldosterone is known to be involved in hypertension, kidney disease, atherosclerosis, and heart failure. Blockade of the aldosterone receptor has been shown to improve cardiovascular function. In congestive heart failure, aldosterone antagonists are used in addition to other drugs for additive diuretic effect, which reduces edema and the cardiac workload.
Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H351,H411
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Classification des risques: Aquatic Chronic 2 - Carc. 2 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable