SML0907

Apoptolidin A Ready Made Solution

1 mg/mL in DMSO

• Synonyme(s) : Apoptolidin, FU 40A
• Formule empirique (notation de Hill): C₅₈H₉₆O₂₁
• Numéro CAS: 194874-06-1
• Poids moléculaire : 1129.37
• Numéro CE : 200-664-3
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825615
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Amycolatopsis sp.
• Niveau de qualité: 200
• Forme: DMSO solution
• Concentration: 1 mg/mL in DMSO
• Spectre d'activité de l'antibiotique: fungi
• Mode d’action: enzyme | inhibits
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: CC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O
• InChI: 1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
• Clé InChI: WILMROCKORZEMQ-XIQAQMKHSA-N

Description

Description générale

Chemical structure: macrolide

Actions biochimiques/physiologiques

Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F₀F₁-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E₁A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F
• Point d'éclair (°C): 87 °C