SML0865

AA92593

≥98% (HPLC)

• Synonyme(s) : 1-(4-Methoxy-3-methyl-benzenesulfonyl)-piperidine, 1-[(4-Methoxy-3-methylphenyl)sulfonyl]-piperidine, Cy1001
• Formule empirique (notation de Hill): C₁₃H₁₉NO₃S
• Numéro CAS: 457961-34-1
• Poids moléculaire : 269.36
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL, clear
• Température de stockage: −20°C
• InChI: 1S/C13H19NO3S/c1-11-10-12(6-7-13(11)17-2)18(15,16)14-8-4-3-5-9-14/h6-7,10H,3-5,8-9H2,1-2H3
• Clé InChI: HDTKLZINZGEPFG-UHFFFAOYSA-N

Description

Application

AA92593 has been used as a selective melanopsin inhibitor.

Actions biochimiques/physiologiques

AA92593 blocks melanopsin activity and stimulates α-melanocyte-stimulating hormone (α-MSH) expression and induces melanin distribution in the melanophores, which darkens the embryo.

AA92593 is an opsinamide, a potent antagonist of melanopsin-mediated phototransduction with an IC₅₀ of 665 nM in a Ca²⁺ flux assay in CHO cells expressing melanopsin (Opn4) and selectivity > 10 μM at 74 common biological targets. AA41612 is believed to act by competing for binding to melanopsin. AA41612 inhibited mouse pupillary light reflex and light aversion in vivo. AA92593 and similar compounds might be useful in alleviating the photophobia associated with migraine.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable