SML0704

1-Methylnicotinamide chloride

≥98% (HPLC)

• Synonyme(s) : 3-Carbamyl-1-methylpyridinium chloride, MNA, N-Methylnicotinic acid amide chloride, N1-Methylnicotinamide chloride
• Formule empirique (notation de Hill): C₇H₉ClN₂O
• Numéro CAS: 1005-24-9
• Poids moléculaire : 172.61
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 15 mg/mL, clear
• Température de stockage: room temp
• InChI: 1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
• Clé InChI: BWVDQVQUNNBTLK-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable