SML0414

NCX 4040

≥98% (HPLC)

• Synonyme(s) : 2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester, NO-aspirin
• Formule empirique (notation de Hill): C₁₆H₁₃NO₇
• Numéro CAS: 287118-97-2
• Poids moléculaire : 331.28
• Numéro MDL: MFCD08062164
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825409
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: white to beige
• Solubilité: DMSO: 15 mg/mL (clear solution)
• Température de stockage: −20°C
• Chaîne SMILES: CC(=O)Oc1ccccc1C(=O)Oc2ccc(CO[N+]([O-])=O)cc2
• InChI: 1S/C16H13NO7/c1-11(18)23-15-5-3-2-4-14(15)16(19)24-13-8-6-12(7-9-13)10-22-17(20)21/h2-9H,10H2,1H3
• Clé InChI: CTHNKWFUDCMLIQ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

NCX 4040 is a nitric oxide-donating form of aspirin.

NCX 4040 is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumor cell lines.

Caractéristiques et avantages

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H317,H318,H400
• Conseils de prudence: P273 - P280 - P302 + P352 - P305 + P351 + P338 + P310
• Classification des risques: Aquatic Acute 1 - Eye Dam. 1 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable