SAB4700352
Monoclonal Anti-IgE antibody produced in mouse
clone 4H10, purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
Anti-IGHE
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
4H10, monoclonal
Forme
buffered aqueous solution
Espèces réactives
human
Concentration
1 mg/mL
Technique(s)
flow cytometry: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... IGHE(3497)
Description générale
Immunoglobulin E (IgE) is encoded by the gene mapped to human chromosome 14q32.33. IgE belongs to the immunoglobulin family and consists of epsilon(ε) heavy chain in the constant (C) region. IgE has a monomeric structure with an extra domain in the constant region.
The antibody 4H10 reacts with human IgE; it recognizes an epitope different from the ones recognized by BE5 and 4G7 antibodies to IgE.
Immunogène
Purified human IgE
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Actions biochimiques/physiologiques
Immunoglobulin E (IgE) binds very tightly to Fc receptors on basophils and mast cells.Thus, it plays a major role in stimulating allergic reactions. Elevated expression of the gene has been associated with the development of hyper IgE Syndrome (HIES), hay fever, atopic skin diseases such as eczema, anaphylactic shock and IgE-myeloma. In addition, overexpression of IgE is also observed in allergy/asthma.Therefore, increased levels of serum IgE can be considered as a diagnosis for asthma. IgE expression is down-regulated in congenital agammaglobulinemia and hypogammaglobulinemia because of faulty metabolism or synthesis of immunoglobulins.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
T Gülen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(9), 1179-1187 (2014-07-22)
The mechanisms by which mast cells in patients with unexplained anaphylaxis (UEA) are triggered remain elusive. Onset of episodes is unpredictable and often recurrent. The substantial overlap between the clinical manifestations of UEA and clonal mast cell disorders (CMD) suggests
Hans D. Ochs, C. I. Edward Smith, Jennifer M.
Primary Immunodeficiency Diseases: A Molecular and Cellular Approach (2006)
Binie Ver Lipps
Immunoglobulin E (Ige): Novel Treatment for Lowering the Concentration of Ige (2009)
N. Franklin Adkinson, Jr., Bruce S. Bochner, Wesley Burks, William W. Busse, Stephen T. Holgate
Middleton's Allergy: Principles and Practice
(2013)
Adriana Turqueti-Neves et al.
European journal of immunology, 44(7), 2130-2138 (2014-04-30)
Infection with helminths and exposure to antigens induce a strong type 2 immune response resulting in the secretion of the cytokines IL-4 and IL-13 by CD4(+) T cells and several innate cell types. IL-4 and IL-13 promote class switch recombination
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