SAB4700313

Monoclonal Anti-HLA-G-Biotin antibody produced in mouse

clone MEM-G/9, purified immunoglobulin, buffered aqueous solution

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Conjugué: biotin conjugate
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: MEM-G/9, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Concentration: 1 mg/mL
• Technique(s): flow cytometry: suitable
• Isotype: IgG1
• Numéro d'accès NCBI: NM_002127.5
• Numéro d'accès UniProt: P17693
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... HLA-G(3135)

Description

Description générale

The antibody MEM-G/9 reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody MEM-G/9 is standard reagent thoroughly validated during 3rd International Conference on HLA-G (Paris, 2003).
Histocompatibility leukocyte antigen–G (HLA-G), a naturally occurring immunosuppressive molecule, is located on human chromosome 6p21. HLA-G gene codes for a tolerogenic protein.

Immunogène

Recombinant human HLA-G refolded with beta2-microglobulin and peptide

Application

The reagent is designed for Flow Cytometry analysis of cells expressing HLA-G molecule on the cell surface using a 1:1000 dilution. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Actions biochimiques/physiologiques

Histocompatibility leukocyte antigen–G (HLA-G) plays an important role in preventing the activities of natural killer (NK) cell and inducing immune escape. It has the ability to block immune competent cells and innate and adaptive immune system. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable