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Key Documents

SAB4504289

Sigma-Aldrich

Anti-phospho-p47 phox (pSer359) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-CGD1, Anti-NCF1A, Anti-NOXO2, Anti-SH3PXD1A, Anti-p47phox

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 44 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P14598

Numéro d'accès UniProt

P14598

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer359)

Informations sur le gène

human ... NCF1(653361)

Description générale

Phospho-p47/ NCF1 (neutrophil cytosolic factor-1) codes for the p47phox subunit of the phagocyte NADPH oxidase (NOX2). It is a cytosolic factor. This gene is located with two pseudogenes (NCF1B and NCF1C). NCF1 is mapped to human chromosome 7q11.23.

Immunogène

The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser359.

Immunogen Range: 331-380

Actions biochimiques/physiologiques

NCF1 (neutrophil cytosolic factor-1) is an important constituent of the phagocyte NADPH-oxidase system. The enzyme helps in the synthesis of microbicidal superoxide in phagocytes like neutrophil and plays a key role in host defense against microbial pathogens. A 2-bp GT deletion in exon 2 of the NCF1 gene results in chronic granulomatous disease (CGD).

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.
Zhao J, et al.
Nature Genetics, 49(3), 433-437 (2017)
Genomic structure of the human p47-phox (NCF1) gene.
Chanock SJ, et al.
Blood Cells, Molecules and Diseases, 26(1), 37-46 (2000)
A copy number variation in human NCF1 and its pseudogenes.
Brunson T, et al.
BMC Genetics, 11(1), 13-13 (2010)
Glaucy Rodrigues de Araújo et al.
Experimental biology and medicine (Maywood, N.J.), 242(3), 333-343 (2017-01-21)
Baccharis trimera, popularly known as "carqueja", is a native South-American plant possessing a high concentration of polyphenolic compounds and therefore high antioxidant potential. Despite the antioxidant potential described for B. trimera, there are no reports concerning the signaling pathways involved

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