SAB4504094
Anti-phospho-p38 MAPK (pTyr322) antibody produced in rabbit
affinity isolated antibody
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 41 kDa
Espèces réactives
mouse, rat, human
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
phosphorylation (pTyr322)
Informations sur le gène
human ... MAPK14(1432)
Description générale
MAPK14 (mitogen-activated protein kinase 14) is a Ser/Thr kinase made of 90 to 360 residues. p38αMAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus. This gene is located on human chromosome 6p21.31.
Immunogène
The antiserum was produced against synthesized peptide derived from human p38 MAPK around the phosphorylation site of Tyr322.
Immunogen Range: 288-337
Immunogen Range: 288-337
Actions biochimiques/physiologiques
MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Polymorphism in MAPK14/p38a leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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MAPK14 (mitogen activated protein kinase 14)
Porras A and Guerrero C
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
MAPK14/p38? confers irinotecan resistance to TP53-defective cells by inducing survival autophagy.
Paillas S, et al.
Autophagy, 8(7), 1098-1112 (2012)
Beom Su Kim et al.
Biochemical and biophysical research communications, 450(4), 1333-1338 (2014-07-09)
Angiogenesis is an important biological process in tissue development and repair. Fucoidan has previously been shown to potentiate in vitro tube formation in the presence of basic fibroblast growth factor (FGF-2). However, the underlying molecular mechanism remains largely unknown. This
D R Mathern et al.
Mucosal immunology, 7(4), 995-1005 (2014-01-16)
The Notch-1 signaling pathway is responsible for homeostatic tight junction expression in vitro, and promotes barrier function in vivo in the RAG1-adoptive transfer model of colitis. In this study, we sought to determine the role of colonic Notch-1 in the
Xin-Juan Fan et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 10487-10495 (2014-07-25)
Phosphorylated p38 (p-p38) played a pivotal role in the regulation of disease progression and correlated with tumor prognosis. Here, we characterized the prognostic effect of p-p38 in colorectal cancer (CRC). Three hundred and sixteen CRC patients in stages I-III were
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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