SAB4504020
Anti-phospho-ATP-Citrate Lyase (pSer454) antibody produced in rabbit
affinity isolated antibody
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 120 kDa
Espèces réactives
mouse, rat, human
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
phosphorylation (pSer454)
Informations sur le gène
human ... ACLY(47)
Catégories apparentées
Description générale
ATP citrate lyase (ACLY) is encoded by the gene mapped to human chromosome 17q21.2. It is localized in the cytoplasm and is widely expressed in mammalian tissues.. ACLY is a 440 KDa tetrameric protein containing four apparently identical subunits.
Immunogène
The antiserum was produced against synthesized peptide derived from human ATP-Citrate Lyase around the phosphorylation site of Ser454.
Immunogen Range: 420-469
Immunogen Range: 420-469
Application
Anti-phospho-ATP-Citrate Lyase (pSer454) antibody produced in rabbit has been used in immunohistochemistry.
Actions biochimiques/physiologiques
ACLY (ATP citrate lyase) is responsible for cleavage of mitochondria-derived citrate to generate oxaloacetic acid (OAA) and acetyl-CoA, which is required for lipid biogenesis. This enzyme couples energy metabolism with fatty acids and facilitates cell growth. In addition, ACLY is also essential for DNA-damage-induced histone acetylation. ACLY is upregulated in several types of cancers and is associated with cancer cell proliferation. Elevated expression of the gene leads to the development of breast cancer. Thus, ACLY -related inhibitors can be considered as a potential strategy for treating breast cancer.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment
Khwairakpam D, et al.
Current Drug Targets, 16(2), 156-163 (2015)
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis.
Wang D, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(4), 1010428317698338-1010428317698338 (2017)
Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age
Elshourbagy N A, et al.
The Journal of Biological Chemistry, 265(3), 1430-1435 (1990)
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination
Sivanand S, et al.
Molecular Cell, 67(2), 252-265 (2017)
Ruiting Lin et al.
Molecular cell, 51(4), 506-518 (2013-08-13)
Increased fatty acid synthesis is required to meet the demand for membrane expansion of rapidly growing cells. ATP-citrate lyase (ACLY) is upregulated or activated in several types of cancer, and inhibition of ACLY arrests proliferation of cancer cells. Here we
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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