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Key Documents

SAB4503840

Sigma-Aldrich

Anti-phospho-WNK1 (pThr58) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 250 kDa

Espèces réactives

rat, human, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q9H4A3

Numéro d'accès UniProt

Q9H4A3

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pThr58)

Informations sur le gène

human ... WNK1(65125)

Description générale

The WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The encoded protein belongs to the WNK kinase family and is ubiquitously expressed.

Immunogène

The antiserum was produced against synthesized peptide derived from human WNK1 around the phosphorylation site of Thr58.

Immunogen Range: 24-73

Actions biochimiques/physiologiques

WNK1 (WNK lysine deficient protein kinase 1) is responsible for maintaining the ion homeostasis. It regulates mitogen-activated protein kinase 7 (MAPK7) mediated cell proliferation and migration. It is also known to promote tumor proliferation, invasion and metastasis in prostate carcinoma. WNK1 expression is essential for vascular remodeling and endothelial sprouting. Autophagy has been indicated in various diseases. This intracellular degradation pathway is prevented by WNK1.(3)

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

A novel homozygous mutation in the WNK1/HSN2 gene causing hereditary sensory neuropathy type 2.}
Potulska-Chromik A, et al.
Acta Biochimica Polonica, 59(3) (2012)
WNK lysine deficient protein kinase 1 regulates human endometrial stromal cell decidualization, proliferation, and migration in part through mitogen-activated protein kinase 7
Adams NR, et al.
Biology of Reproduction, 97(3), 400-412 (2017)
Multistep regulation of autophagy by WNK1
Gallolu Kankanamalage S, et al.
Proceedings of the National Academy of Sciences of the USA, 113(50), 14342-14347 (2016)
Stefanie Albrecht et al.
Glia, 67(5), 870-883 (2019-01-10)
In multiple sclerosis, demyelination occurs as a consequence of chronic autoimmunity in the central nervous system causing progressive neurological impairment in patients. After a demyelinating event, new myelin sheaths are formed by adult oligodendroglial progenitor cells; a process called remyelination.

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