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Key Documents

SAB4503544

Sigma-Aldrich

Anti-Claudin 2 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CLD2, CLDN2, SP82, claudin-2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 24 kDa

Espèces réactives

human, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P57739

Numéro d'accès UniProt

P57739

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CLDN2(9075)

Catégories apparentées

Description générale

Anti-Claudin 2 Antibody detects endogenous levels of total Claudin 2 protein.
Claudin-2 is one of the pore-forming claudins. It is a member of the claudin family of proteins. Claudin-2 is present in the proximal tubules. It is mapped to human chromosome Xq22.

Immunogène

The antiserum was produced against synthesized peptide derived from human Claudin 2.

Immunogen Range: 181-230

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Actions biochimiques/physiologiques

The tetraspan membrane protein encoded by claudin multigene controls paracellular permeability and maintaining cell polarity in epithelial and endothelial cell sheets. In MDCK (madin-darby canine kidney cells) II cells, claudin-2 participates in the generation of aqueous pores with high conductance.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The claudins
Lal-Nag M and Morin P J
Genome Biology (2009)
Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells
Furuse M, et al.
The Journal of Cell Biology, 153(2), 263-272 (2001)
Inga B Christensen et al.
Frontiers in physiology, 4, 344-344 (2013-12-19)
The choroid plexus epithelium (CPE) has served as a model-epithelium for cell polarization and transport studies and plays a crucial role for cerebrospinal fluid (CSF) production. The normal luminal membrane expression of Na(+),K(+)-ATPase, aquaporin-1 and Na(+)/H(+) exchanger 1 in the
Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-? Treated Cell Monolayers
Zhang C, et al.
International Journal of Molecular Sciences, 18(1) (2017)
Tumor necrosis factor-? induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions
Amoozadeh Y, et al.
American Journal of Physiology. Cell Physiology, 309(1), C38-C50 (2015)
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