Accéder au contenu
MilliporeSigma
Toutes les photos(2)

Key Documents

SAB4502850

Sigma-Aldrich

Anti-SREBP-1 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

SRBP1, SREBF1, SREBP1, sterol regulatory element-binding protein 1, sterol regulatory element-binding transcription factor 1

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Numéro MDL:
MFCD02264110
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 121 kDa

Espèces réactives

human, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P36956

Numéro d'accès UniProt

P36956

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SREBF1(6720)

Catégories apparentées

Description générale

Anti-SREBP-1 Antibody detects endogenous levels of total SREBP-1 protein.
Sterol regulatory element binding protein-1 (SREBP1) is located on human chromosome 17p11.2. It belongs to the bHLH-Zip transcription factor family. SREBP-1 is a membrane-bound transcription factor liberated by sterol-regulated proteolysis.It is a 125 kD precursor that is bound to the nuclear envelope and endoplasmic reticulum.

Immunogène

The antiserum was produced against synthesized peptide derived from human SREBP-1.

Immunogen Range: 405-454

Actions biochimiques/physiologiques

Sterol regulatory element binding protein-1 (SREBP1) participates in the transcriptional regulation of cellular lipid homeostasis. It controls the hepatic gene expression of lipogenic enzymes and triglyceride deposition in the liver.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Vous ne trouvez pas le bon produit ?  

Essayez notre Outil de sélection de produits.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Absence of sterol regulatory element-binding protein-1 (srebp-1) ameliorates fatty livers but not obesity or insulin resistance inlep ob/lep ob mice.
Yahagi N, et al.
The Journal of Biological Chemistry, 277(22), 19353-19357 (2002)
The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility.
Linser R, et al.
Proceedings of the National Academy of Sciences of the USA, 112(40), 12390-12395 (2015)
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11. 2 and 22q13.
Hua X, et al.
Genomics, 25(3), 667-673 (1995)
Chien-Chih Chen et al.
Scientific reports, 7(1), 10901-10901 (2017-09-09)
Atypical antipsychotics (AAPs) are considered to possess superior efficacy for treating both the positive and negative symptoms of schizophrenia; however, AAP use often causes excessive weight gain and metabolic abnormalities. Recently, several reports have demonstrated that AAPs activate sterol regulatory
Mathieu Schmitt et al.
Synapse (New York, N.Y.), 71(9) (2017-04-14)
The therapeutic use of statins has been associated to a reduced risk of Parkinson's disease (PD) and may hold neuroprotective potential by counteracting the degeneration of dopaminergic neurons. Transcriptional activation of the sterol regulatory element-binding protein (SREBP) is one of
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique