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Key Documents

SAB4501657

Sigma-Aldrich

Anti-Keratin 14 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CK-14, Cytokeratin-14, K14, Keratin type I cytoskeletal 14

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 51 kDa

Espèces réactives

mouse, human, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P02533

Numéro d'accès UniProt

P02533

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... KRT14(3861)

Description générale

Anti-Keratin 14 Antibody detects endogenous levels of total Keratin 14 protein.
CK14/ KRT14 (keratin 14) is one of the cytokeratin isotypes of human cells. It is the intermediate filament protein, which is the feature of epithelial cells. It is located in human chromosome 17q21.

Immunogène

The antiserum was produced against synthesized peptide derived from human Keratin 14.

Immunogen Range: 1-50

Actions biochimiques/physiologiques

CK14/ KRT14 (keratin 14) participates in the collective invasion of salivary adenoid cystic carcinoma (SACC). Mutations in KRT14 results in epidermolysis bullosa simplex.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Maree Bilandzic et al.
Cancers, 11(9) (2019-08-25)
Epithelial ovarian cancer metastasis is driven by spheroids, which are heterogeneous cancer cell aggregates released from the primary tumour mass that passively disseminate throughout the peritoneal cavity to promote tumour spread, disease recurrence, and acquired chemoresistance. Despite their clinical importance
Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.
Gao XL, et al.
PLoS ONE, 12(2), e0171341-e0171341 (2017)
KRT14 Haploinsufficiency Results in Increased Susceptibility of Keratinocytes to TNF-?-Induced Apoptosis and Causes Naegeli?Franceschetti?Jadassohn Syndrome.
Lugassy J, et al.
The Journal of Investigative Dermatology, 128(6), 1517-1524 (2008)
Mariaceleste Aragona et al.
Nature, 584(7820), 268-273 (2020-07-31)
The ability of the skin to grow in response to stretching has been exploited in reconstructive surgery1. Although the response of epidermal cells to stretching has been studied in vitro2,3, it remains unclear how mechanical forces affect their behaviour in
Carlos Gomez-Diaz et al.
iScience, 24(11), 103241-103241 (2021-11-11)
The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell types. HOIL-1L contains an Npl4 Zinc Finger (NZF) domain that specifically recognizes linear ubiquitin chains, but its

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