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Key Documents

SAB4500823

Sigma-Aldrich

Anti-PAR1 (Cleaved-Ser42), N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CXCR-7, CXCR7, G-protein coupled receptor 159, G-protein coupled receptor RDC1, chemokine orphan receptor 1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 46 kDa

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

Numéro d'accès NCBI

P25116

Numéro d'accès UniProt

P25116

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

proteolytically cleaved (Ser42)

Informations sur le gène

human ... F2R(2149)

Description générale

Anti-PAR1 (Cleaved-Ser42) Antibody detects endogenous levels of fragment of activated PAR1 (Cleaved-Ser42) protein.
Protease-activated receptor-1 (PAR1), also known as coagulation factor II thrombin receptor (F2R), is encoded by the gene mapped to human chromosome 5q13.3. The encoded protein is a cell surface seven-transmembrane G protein coupled receptor.

Immunogène

The antiserum was produced against synthesized peptide derived from human PAR1.

Immunogen Range: 23-72

Application

Anti-PAR1 (Cleaved-Ser42), N-Terminal antibody produced in rabbit has been used in Western blotting.

Actions biochimiques/physiologiques

Protease-activated receptor-1 (PAR1) facilitates angiogenesis and influences the process of tumor growth and disease progression. In addition, it also plays a vital role in inflammation and thrombosis. Mutation in the gene is associated with an increased risk of metastasis and poorer prognosis of renal cell carcinoma. Elevated expression of the gene has been observed in various types of cancers, such as ovarian, breast, lung, prostate cancer and melanoma.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer.
Lin C, et al.
BMC Cancer, 17(1), 113-113 (2017)
Barry S Shea et al.
JCI insight, 2(9) (2017-05-05)
Fibrotic lung disease, most notably idiopathic pulmonary fibrosis (IPF), is thought to result from aberrant wound-healing responses to repetitive lung injury. Increased vascular permeability is a cardinal response to tissue injury, but whether it is mechanistically linked to lung fibrosis
Zhuang-Zhuang Tang et al.
Naunyn-Schmiedeberg's archives of pharmacology (2021-11-19)
Upregulation of thrombin receptor protease-activated receptor 1 (PAR-1) is verified to contribute to chronic kidney diseases, including diabetic nephropathy; however, the mechanisms are still unclear. In this study, we investigated the effect of PAR-1 on high glucose-induced proliferation of human
Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.
Shea B S, et al.
JCI insight, 2(9) (2017)
The protease activated receptor 1 gene variation IVSn?14 A> T is associated with distant metastasis and cancer specific survival in renal cell carcinoma.
de Martino M, et al.
The Journal of Urology, 190(4), 1392-1397 (2013)
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