SAB4301167
Anti-MTFP1 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
HSPC242, MTP18
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
18 kDa
Espèces réactives
human, mouse
Concentration
1.8 mg/mL
Technique(s)
immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)
Isotype
IgG
Numéro d'accès
NP_001003704.1
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... MTFP1(51537)
Description générale
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18), a nuclear-encoded integral protein, is located in the mitochondria. It is also a phosphatidylinositol 3-kinase-dependent protein. MTP18 comprises three α-helical stretches or transmembrane (TM) domains of high hydrophobicity. The MTFP1 gene is located on human chromosome 22q12.2.
Spécificité
The antibody detects endogenous levels of total MTFP1 protein.
Immunogène
Fusion protein corresponding to a region derived from internal residues of human mitochondrial fission process 1
Application
Anti-MTFP1 antibody produced in rabbit has been used in western blot (1:1000).
Actions biochimiques/physiologiques
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18) controls mitochondrial fission Hence it helps to maintain the morphology of the mitochondria. Overexpression of MTP18 can facilitate fragmentation of the mitochondria. Loss-of-function of MTFP1 protein promotes cell death. It is crucial for cell viability.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Aleix Prat et al.
Breast cancer research and treatment, 147(1), 185-191 (2014-07-23)
BRCA1-mutated breast cancer is associated with basal-like disease; however, it is currently unclear if the presence of a BRCA1 mutation depicts a different entity within this subgroup. In this study, we compared the molecular features among basal-like tumors with and
Daniel Tondera et al.
Journal of cell science, 118(Pt 14), 3049-3059 (2005-06-30)
Mitochondria are dynamic organelles that change morphology by controlled fission and fusion events. Mitochondrial fission is regulated by a conserved protein complex assembled at the outer membrane. Human MTP18 is a novel nuclear-encoded mitochondrial membrane protein, implicated in controlling mitochondrial
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Tingying Xiao et al.
Cell biology international, 44(3), 821-829 (2019-12-10)
Mitochondrial fission process 1 (MTFP1) is a novel nuclear-encoded protein that promotes mitochondrial fission. Increasing lines of evidence indicate that increased mitochondrial fission is involved in carcinogenesis and tumor progression. However, the expression and biological effects of MTFP1 in cancer
Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress.
Lynn H H Aung et al.
Clinical science (London, England : 1979), 133(9), 1067-1084 (2019-04-25)
Accumulation of reactive oxygen species is a common phenomenon in cardiac stress conditions, for instance, coronary artery disease, aging-related cardiovascular abnormalities, and exposure to cardiac stressors such as hydrogen peroxide (H2O2). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner
Arne Jahn et al.
EMBO reports, 18(6), 929-946 (2017-05-14)
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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