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SAB4301113

Sigma-Aldrich

Anti-RAS antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CTLO, HAMSV, HRAS1, K-RAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

21 kDa

Espèces réactives

mouse, rat, human

Concentration

0.7 mg/mL

Technique(s)

western blot: 1:200-1:1000 (Cell Lysate)

Isotype

IgG

Numéro d'accès

NP_001123914.1

Numéro d'accès UniProt

P01112

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HRAS(3265)

Description générale

Ras is a proto-oncogene and the gene encoding it is localized on human chromosome 11p15.5. It is a 21 kDa protein and is part of the small GTP-binding proteins superfamily.

Spécificité

The antibody detects endogenous level of total RAS protein.

Immunogène

Synthetic peptide corresponding to a region derived from 60-74 amino acids of Human v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Actions biochimiques/physiologiques

Ras is a guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to mitogen activated protein (MAP) kinase cascade. It has an important role in cell growth. Ras is a substrate for farnesyltransferase (FTase) and when farnesylated, it is anchored to the membrane. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for anti-cancer drug development.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat structural evidence for a 11p15. 5 gene family.
Desseyn J L, et al.
The Journal of Biological Chemistry, 272(6), 3168-3178 (1997)
Germline mutations in HRAS proto-oncogene cause Costello syndrome.
Aoki Y, et al.
Nature Genetics, 37(10), 1038-1038 (2005)
Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS.
Spoerner M, et al.
Febs Letters, 274(6), 1419-1433 (2007)
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.
Rowinsky E K, et al.
Journal of Clinical Oncology, 7(11), 3631-3652 (1999)
Evaluation of CAAX prenyl protease II of Leishmania donovani as potential drug target: Infectivity and growth of the parasite is significantly lowered after the gene knockout.
Bhardwaj R, et al.
European Journal of Pharmaceutical Sciences, 102, 156-160 (2017)

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