SAB4300655
Anti-Integrin β1 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
Anti-FNRB, Anti-ITGB1, Anti-MDF2, Anti-MSK12, Anti-VLAB
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
115-135 kDa
Espèces réactives
mouse, rat, human
Concentration
1 mg/mL
Technique(s)
western blot: 1:500-1:1000
Isotype
IgG
Séquence immunogène
(V-V-N-P-K)
Numéro d'accès NCBI
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... ITGB1(3688)
Description générale
Integrin β1 is a mechanosensor , that is located on chromosome 10p11.22. It is present in normal cells and tumor-associated cells.
The antibody detects endogenous level of total Integrin β1 (CD29) protein.
The antibody detects endogenous level of total Integrin β1 (CD29) protein.
Immunogène
Peptide sequence around aa. 790-794 (V-V-N-P-K), according to the protein NP_002202.2
Application
Anti-Integrin β1 antibody has been used in immunofluorescence and western blotting.
Actions biochimiques/physiologiques
Integrin β1 acts as an adhesive molecule in the development of de novo focal contact, keratinocyte migration and re-epithelization of wound tissue.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Description de la cible
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi′s sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis
Forme physique
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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?1 integrin signaling in asymmetric migration of keratinocytes under mechanical stretch in a co-cultured wound repair model
Lu D, et al.
BioMedical Engineering OnLine (2016)
Electric field exposure promotes epithelial?mesenchymal transition in human lens epithelial cells via integrin ?1?FAK signaling
Liu J, et al.
Molecular Medicine Reports (2017)
Genomic aberrations associated with erlotinib resistance in non-small cell lung cancer cells
Serizawa M, et al.
Anticancer Research (2013)
?1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer
Yin HL, et al.
International Journal of Molecular Sciences (2016)
Yanhua Fang et al.
Cancer cell international, 22(1), 364-364 (2022-11-20)
Radiotherapy is one of the essential treatment modalities for nasopharyngeal carcinoma (NPC), however, radioresistance still poses challenges. Three-dimensional (3D) tumor culture models mimic the in vivo growth conditions of cells more accurately than 2D models. This study is to compare
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