SAB4300361

Anti-ITGB3 (Ab-773) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-CD61 antibody produced in rabbit, Anti-GP3A antibody produced in rabbit, Anti-GPIIIa antibody produced in rabbit, Anti-integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) antibody produced in rabbit
• Numéro MDL: MFCD00211790
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~110 kDa
• Espèces réactives: human, rat, mouse
• Concentration: 1 mg/mL
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (P-L-Y-K-E)
• Numéro d'accès NCBI: NP_000203.2
• Numéro d'accès UniProt: P05106
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... ITGB3(3690)

Description

Description générale

ITGB3 (integrin subunit β3) codes for integrin αIIbβ3. It is located on human chromosome 17q21.31-32.

Immunogène

Peptide sequence around aa. 771-775 (P-L-Y-K-E), according to the protein ITGB3.

Actions biochimiques/physiologiques

Mutations in ITGB3 (integrin subunit β3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells, promoted by reactive oxygen species.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable