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SAB4200706

Sigma-Aldrich

Anti-TM4SF4 antibody, Mouse monoclonal

clone TM4SF-11, hybridoma cell culture supernatant

Synonyme(s) :

Anti-ILTMP, Anti-il-TMP transmembrane 4 L six family member 4

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Forme d'anticorps

culture supernatant

Niveau de qualité

200

Type de produit anticorps

primary antibodies

Clone

TM4SF-11, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~27 kDa

Espèces réactives

rat, human, canine, monkey, mouse, bovine

Technique(s)

immunoblotting: 1:4,000-1:8,000 using whole extract of HCT-116 cells

Isotype

IgM

Numéro d'accès UniProt

P48230

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TM4SF4(7104)
mouse ... Tm4sf4(229302)
rat ... Tm4sf4(116467)

Description générale

Anti-TM4SF4 antibody, Mouse monoclonal (mouse IgM isotype) is derived from the TM4SF-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide from the internal region of human TM4SF4, conjugated to KLH. TM4SF4 (Transmembrane 4 L6 Family member 4) also known as ILTMP (intestine and liver tetraspan membrane protein) is a member of the transmembrane 4 superfamily (or tetraspanin family). It is a cell surface glycoprotein containing four transmembrane domains.

Immunogène

synthetic peptide from the internal region of human TM4SF4

Application

Anti-TM4SF4 antibody has been used in immunoblotting.

Actions biochimiques/physiologiques

TM4SF4 (Transmembrane 4 L6 Family member 4) can intervene density-dependent cell proliferation. TM4SF4 levels increases in non-dividing epithelial cells during their differentiation and migration of intestinal crypts. TM4SF4 levels are upregulated in 80% of hepatocellular carcinoma (HCC) tissues and in stomach adenocarcinoma cells. Reduction of TM4SF4 expression in HCC cell lines by stably transfecting TM4SF4 antisense plasmid caused significant inhibition of cell proliferation.

Forme physique

The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
076M4806V

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Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth
Li Y, et al.
Acta biochimica et biophysica Sinica, 44(3), 224-232 (2012)
Soo-Im Choi et al.
Oncotarget, 5(20), 9823-9837 (2014-10-27)
Transmembrane 4 L six family member 4 (TM4SF4) is a member of the tetraspanin L6 domain family. Other members of this family, TM4SF1 (also known as L6-Ag) and TM4SF5, have been shown to be upregulated in multiple tumors and involved
B M Wice et al.
The Journal of biological chemistry, 270(37), 21907-21918 (1995-09-15)
The human cell line HT-29 provides a model system for studying regulation of proliferation and differentiation in intestinal epithelial cell lineages: (i) HT-29 cells cultured in glucose resemble undifferentiated multipotent transit cells located in the lower half of intestinal crypts;
Ying Li et al.
Acta biochimica et biophysica Sinica, 44(3), 224-232 (2012-01-13)
The human transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein (TM4SF4/il-TMP) was originally cloned as an intestinal and liver tetraspan membrane protein and mediates density-dependent cell proliferation. The rat homolog of TM4SF4 was found to be

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