SAB4200666
Anti-MR−Pro ADM antibody produced in rabbit
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About This Item
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.43
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Forme
buffered aqueous solution
Poids mol.
antigen ~5 kDa
Espèces réactives
human
Concentration
~1 mg/mL
Technique(s)
immunoblotting: 0.25-0.5 g/mL
immunofluorescence: 2.5-5 μg/mL
immunohistochemistry: 10-20 μg/mL
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... ADM(133)
Description générale
MR-pro-ADM (mid-regional-pro-adrenomedullin) is a 47-residue long peptide, produced during posttranslational processing of adrenomedullin. It has a molecular weight of 5.1kDa. Adrenomedullin (ADM) is a vasodilator peptide, which is produced and released by a wide variety of cells such as, macrophages, fibroblasts, cardiomyocytes etc. MR-pro-ADM functions as a substitute marker for ADM. This peptide is coded by the gene localized to human chromosome 11p15.4, which is composed of four exons and three introns.
Immunogène
a synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM) , conjugated to KLH.
Actions biochimiques/physiologiques
In hemodialysis patients increased plasma levels of MR-pro-ADM (mid-regional-pro-adrenomedullin) is linked with decreased survival. This is due to increased vasodilation in response to higher levels of MR-pro-ADM; lower levels of this peptide result in increased vasoconstriction and hence, better prognosis. This peptide is also associated with increased cardiovascular mortality in dialysis patients. In type II diabetic patients, MR-pro-ADM peptide is linked with renal outcome, as adrenomedullin (ADM) gene regulates susceptibility to nephropathic progression.
Forme physique
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Adrenomedullin and tumour microenvironment.
Larrayoz IM et al
Journal of Translational Medicine, 12, 339-339 (2014)
Plasma Adrenomedullin and Allelic Variation in the ADM Gene and Kidney Disease in People With Type 2 Diabetes.
Velho G et al
Diabetes, 64(9), 3262-3272 (2015)
N Minamino et al.
Clinical hemorheology and microcirculation, 23(2-4), 95-102 (2001-04-26)
Adrenomedullin (AM) is a vasodilator peptide first identified in pheochromocytoma tissue, but endothelial cells and vascular smooth muscle cells actively secrete AM in addition to expressing AM receptors. AM dilates blood vessels through its direct action on the smooth muscle
Ghazaleh Gouya et al.
PloS one, 6(3), e17803-e17803 (2011-03-17)
High levels of the plasma peptides mid-regional pro-adrenomedullin (MR-proADM) and mid-regional pro-atrial natriuretic peptide (MR-proANP) are associated with clinical outcomes in the general population. Data in patients with chronic kidney disease are sparse. We therefore investigated the association of MR-proANP
Ferruh Artunc et al.
PloS one, 9(1), e86148-e86148 (2014-01-28)
Vasopressin, endothelin and adrenomedullin are vasoactive peptides that regulate vascular tone and might play a role in hypertensive diseases. Recently, laboratory assays have been developed to measure stable fragments of vasopressin, endothelin and adrenomedullin. Little is known about their diagnostic
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