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SAB4200068

Sigma-Aldrich

Anti-PSPC1 (N-terminal) antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

Synonyme(s) :

Anti-PSP1, Anti-Paraspeckle protein 1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~59 kDa

Espèces réactives

human

Validation améliorée

independent
Learn more about Antibody Enhanced Validation

Concentration

~1.0 mg/mL

Technique(s)

indirect immunofluorescence: 1.2-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells
western blot (chemiluminescent): 0.5-1 μg/mL using lysates of HEK-293T cells

Numéro d'accès UniProt

Q8WXF1

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PSPC1(55269)

Catégories apparentées

Description générale

Paraspeckle protein 1 (PSP1/ PSPC1) has two isoforms, α and β. PSPC1 belongs to the Drosophila melanogaster behavior, human splicing (DBHS) protein family.

Application

Anti-PSPC1 (N-terminal) antibody produced in rabbit may be used in several immunochemical techniques including immunoblotting (~59 kDa) and immunofluorescence. It has also been used in RNA immunoprecipitation (RIP) experiment.

Actions biochimiques/physiologiques

Paraspeckle protein 1(PSP1/ PSPC1) is implicated in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor, and in a wide range of processes such as transcription, splicing, and RNA metabolism. It acts as a marker for paraspeckles, which are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei that are often located adjacent to splicing speckles.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Circadian RNA expression elicited by 3?-UTR IRAlu-paraspeckle associated elements
Torres M, et al.
eLife, 5(9), e14837-e14837 (2016)
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold
Knott GJ, et al.
Nucleic Acids Research, 44(9), 3989-4004 (2016)
P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner
Fox AH, et al.
Molecular Biology of the Cell, 16(11), 5304-5315 (2005)
Manon Torres et al.
eLife, 5 (2016-07-22)
Paraspeckles are nuclear bodies form around the long non-coding RNA, Neat1, and RNA-binding proteins. While their role is not fully understood, they are believed to control gene expression at a post-transcriptional level by means of the nuclear retention of mRNA
Luisa Gabriel et al.
Journal of cell science, 134(10) (2021-05-27)
Zα domains recognize the left-handed helical Z conformation of double-stranded nucleic acids. They are found in proteins involved in the nucleic acid sensory pathway of the vertebrate innate immune system and host evasion by viral pathogens. Previously, it has been
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