SAB3500654
Anti-SIGLEC15 antibody produced in rabbit
affinity isolated antibody
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Poids mol.
36 kDa
Espèces réactives
human, rat, mouse
Concentration
1 mg/mL
Technique(s)
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... SIGLEC15(284266)
Catégories apparentées
Description générale
Sialic acid binding Ig like lectin 15 (SIGLEC15) is part of the Siglec family of glycan-recognition proteins. It is expressed in a subset of macrophages. This type-I transmembrane protein possesses two immunoglobulin-like domains, a transmembrane domain and a short cytoplasmic tail. The SIGLEC15 gene is localized on human chromosome 18q12.3.
Immunogène
Antibody was raised against a 15 amino acid peptide near the amino terminus of human SIGLEC15.
Actions biochimiques/physiologiques
Sialic acid binding Ig like lectin 15 (SIGLEC15) recognizes a tumor-linked glycan structure called the sialyl-Tn (sTn) antigen. It is expressed on tumor-associated macrophages in tumor tissues. The protein acts as a signal transducer. SIGLEC15 associates with the adaptor protein DNAX activation protein of 12kDa (DAP12) and transduces a signal to spleen tyrosine kinase (Syk).
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Liaison
The action of this antibody can be blocked using blocking peptide SBP3500654.
Forme physique
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.
Glycobiology (2007)
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-? secretion from monocytes/macrophages through the DAP12-Syk pathway.
Takamiya R
Glycobiology (2013)
Jiao Hu et al.
Theranostics, 11(7), 3089-3108 (2021-02-05)
Rationale: Siglec15 is an emerging target for normalization cancer immunotherapy. However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of Siglec15 in bladder cancer (BLCA) remains elusive. Methods: We comprehensively evaluated the expression pattern and immunological role
Kaiqin Sheng et al.
International journal of molecular sciences, 24(1) (2023-01-09)
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) has been identified as a crucial immune suppressor in human cancers, comparable to programmed cell death 1 ligand (PD-L1). However, the regulatory mechanisms underlying its transcriptional upregulation in human cancers remain largely unknown. Here
Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region
Huan Cao
Immunogenetics, 401-477 (2009)
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