SAB2101106

Anti-HTR2A antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-5-HT2A, Anti-5-hydroxytryptamine (serotonin) receptor 2A, Anti-HTR2
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 52 kDa
• Espèces réactives: human
• Concentration: 0.5 mg - 1 mg/mL
• Technique(s): western blot: suitable
• Numéro d'accès UniProt: P28223
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... HTR2A(3356)

Description

Description générale

5-hydroxytryptamine receptor 2A (HTR2A) encodes for a G-Protein coupled serotonin receptor. HTR2A is predominantly expressed in the brain near to serotoninergic neurons. The gene HTR2A is localized on human chromosome on 13q14.2.

Immunogène

Synthetic peptide directed towards the N terminal region of human HTR2A

Actions biochimiques/physiologiques

5-hydroxytryptamine receptor 2A (HTR2A) binds to neurotransmitters or drugs and activates the G-protein coupled signalling pathway by stimulating phospholipase C signalling cascade and the ultimate release of calcium. and modulates cognitive functions, memory, learning etc. HTR2A is the drug targeting receptor for many of the antipsychotic drugs like serotonergic psychedelics. Genetic polymorphisms as well as epigenetic factors regulate the expression of HTR2A. These variations in the regulation lead to a wide variety of psychotic disorders like schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer′s disease.

Séquence

Synthetic peptide located within the following region: DILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSEN

Forme physique

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable