SAB1405747
Anti-EGR2 antibody produced in mouse
purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
AT591, CMT1D, CMT4E, DKFZp686J1957, FLJ14547, KROX20
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen ~50.3 kDa
Espèces réactives
human
Technique(s)
indirect immunofluorescence: suitable
western blot: 1 μg/mL
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... EGR2(1959)
Catégories apparentées
Description générale
Early growth response 2 (EGR2) is a zinc finger transcription factor and a member of the EGR family. Structurally, it comprises activation domain(A), DNA binding domain (DBD) zinc finger domain, basic domain (BD) and broadly neutralizing antibody (BNab) interaction domain(R1). The EGR2 gene is mapped to human chromosome 10q21.3.
Immunogène
EGR2 (NP_000390.2, 1 a.a. ~ 476 a.a) full-length human protein.
Sequence
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP
Sequence
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP
Actions biochimiques/physiologiques
Early growth response 2 (EGR2) is essential for peripheral nerve myelination and T cell anergy. It is also needed for the formation of gap junction beta 1 (GJB1) and periaxin along with other myelin proteins. Mutations in the EGR2 gene are implicated in peripheral neuropathies namely Charcot-Marie-Tooth disease type 1 (CMT1), congenital hypomyelinating neuropathy (CHN), and Dejerine-Sottas neuropathy (DSN/CMT). EGR2 upregulation may regulate inflammatory cytokines during recovery from Guillain-Barré syndrome (GBS).
Forme physique
Solution in phosphate buffered saline, pH 7.4
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3 and EGR2 on chromosome 10.
B Van Der Zwaag et al.
Journal of medical genetics, 39(6), E30-E30 (2002-06-19)
Kota Noritsugu et al.
Biochemical and biophysical research communications, 489(4), 455-459 (2017-06-04)
EGR2 is a zinc finger transcription factor that regulates myelination in the peripheral nervous system and T cell anergy. The transcriptional activity of EGR2 is known to be regulated by its co-activators and/or co-repressors. Although the activity of transcription factors
Ernesto Doncel-Pérez et al.
Journal of immunology (Baltimore, Md. : 1950), 196(3), 1102-1107 (2016-01-01)
Guillain-Barré syndrome (GBS) is an immune-mediated peripheral neuropathy. The goal of this research was the identification of biomarkers associated with recovery from GBS. In this study, we compared the transcriptome of PBMCs from a GBS patient and her healthy twin
Roseline Poirier et al.
Frontiers in neuroscience, 2(1), 47-55 (2008-11-05)
The different gene members of the Egr family of transcriptional regulators have often been considered to have related functions in brain, based on their co-expression in many cell-types and structures, the relatively high homology of the translated proteins and their
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