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Key Documents

SAB1100322

Sigma-Aldrich

Anti-RNF4 (176-190) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Anti-RES4-26, Anti-Ring finger protein 4, Anti-SNURF

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~21 kDa

Espèces réactives

human

Technique(s)

western blot: 1:500-1:2,000

Numéro d'accès UniProt

P78317

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... RNF4(6047)

Description générale

Really interesting new gene (RING ) finger protein 4 (RNF4) gene encodes ubiquitin E3 ligase, an enzyme widely expressed in many tissues. The protein contains a RING (really interesting new gene) finger domain and around three small ubiquitin-related modifier (SUMO)-interaction motifs. RNF4 is mapped to human chromosome 4p16.3.

Immunogène

synthetic peptide corresponding to amino acids 176-190 of human RNF4

Application

Anti-RNF4 (176-190) antibody produced in rabbit has been used in western blotting analysis.

Actions biochimiques/physiologiques

Really interesting new gene (RING ) finger protein 4 (RNF4) catalyzes the ubiquitylation of proteins associated with small ubiquitin-related modifier (SUMO). Rnf4 is involved in DNA repair, in transcription and chromatin regulation. It is also associated with the process of hematopoiesis. RNF4 is implicated in acute promyelocytic leukemia, acute myeloid leukemia, Fanconi anemia and aplastic anemia.

Description de la cible

RNF4 (176-190), ring finger protein 4. encodes a protein that contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
Wang WF, et al.
Nature Communications, 8(1), 363-363 (2017)
RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors
Pero R, et al.
The American Journal of Pathology, 159(4), 1225-1230 (2001)
RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPalpha axis
Wang L, et al.
Faseb Journal, 32(9), 4930-4940 (2018)
E1B-55K-mediated regulation of RNF4 SUMO-targeted ubiquitin ligase promotes human adenovirus gene expression
Muncheberg S, et al.
Journal of Virology, 92(13), e00164-e00118 (2018)
Wen-Fang Wang et al.
Nature communications, 8(1), 363-363 (2017-08-27)
B lymphocyte-induced maturation protein-1 (Blimp-1) ensures B-cell differentiation into the plasma cell stage, and its instability constitutes a crucial oncogenic element in certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL). However, the underlying degradation mechanisms and

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