PZ0328

PF-4800567 hydrochloride

≥98% (HPLC)

• Synonyme(s) : 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride, PF 4800567
• Formule empirique (notation de Hill): C₁₇H₁₈ClN₅O₂ · HCl
• Numéro CAS: 1391052-28-0
• Poids moléculaire : 396.27
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C17H18ClN5O2.ClH/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12;/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21);1H
• Clé InChI: QZXZQMUZEHTFHD-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC₅₀ = 32 nM) that is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.

PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl.

Autres remarques

PF-4800567 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF-4800567 probe summary on the Chemical Probes Portal website.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable