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Key Documents

Autres documents

PZ0233

Sigma-Aldrich

PF-06424439

≥98% (HPLC)

Synonyme(s) :

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

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About This Item

Formule empirique (notation de Hill):
C22H26ClN7O · CH3SO3H
Numéro CAS:
1469284-79-4
Poids moléculaire :
536.05
Code UNSPSC :
12352200
ID de substance PubChem :
329823784

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Activité optique

[α]/D +7 to +11°, c = 1.0 in methanol

Couleur

white to light brown

Solubilité

H2O: 10 mg/mL, clear

Température de stockage

room temp

Chaîne SMILES 

O=C([C@@H]1CCCN(C2=NC(NC(C3(CC3)N4N=CC(Cl)=C4)=N5)=C5C=C2)C1)N6CCCC6.CS(=O)(O)=O

InChI

1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1

Clé InChI

ZSTFDNQQOJUJFL-XFULWGLBSA-N

Application

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2) inhibitor:
  • to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
  • to study its effects on HeLa cells
  • to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Actions biochimiques/physiologiques

PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.
PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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