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P6062

Sigma-Aldrich

Protein Kinase A Inhibitor Fragment 6-22 amide

≥97% (HPLC)

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About This Item

Formule empirique (notation de Hill):
C80H130N28O24
Numéro CAS:
121932-06-7
Poids moléculaire :
1868.06
Numéro MDL:
MFCD00133792
Code UNSPSC :
12352202
ID de substance PubChem :
329820240
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

≥97% (HPLC)

Forme

powder

Température de stockage

−20°C

Chaîne SMILES 

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(N)=O

InChI

1S/C80H130N28O24/c1-10-37(3)60(63(83)118)106-66(121)41(7)96-72(127)52(32-55(81)113)103-69(124)49(22-17-29-92-80(88)89)100-68(123)47(20-15-27-90-78(84)85)98-57(115)35-94-76(131)62(43(9)111)108-70(125)48(21-16-28-91-79(86)87)99-56(114)34-93-67(122)54(36-109)105-65(120)40(6)97-77(132)61(38(4)11-2)107-74(129)51(30-44-18-13-12-14-19-44)102-73(128)53(33-58(116)117)101-64(119)39(5)95-71(126)50(104-75(130)59(82)42(8)110)31-45-23-25-46(112)26-24-45/h12-14,18-19,23-26,37-43,47-54,59-62,109-112H,10-11,15-17,20-22,27-36,82H2,1-9H3,(H2,81,113)(H2,83,118)(H,93,122)(H,94,131)(H,95,126)(H,96,127)(H,97,132)(H,98,115)(H,99,114)(H,100,123)(H,101,119)(H,102,128)(H,103,124)(H,104,130)(H,105,120)(H,106,121)(H,107,129)(H,108,125)(H,116,117)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t37-,38-,39-,40-,41-,42+,43+,47-,48-,49-,50-,51-,52-,53-,54-,59-,60-,61-,62-/m0/s1

Clé InChI

VAKHFAFLRUNHLQ-PEBJKXEYSA-N

Amino Acid Sequence

Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

Application

Protein Kinase A Inhibitor Fragment 6-22 amide has been used as a PKA inhibitor:
  • to study its effects on oocytes in two-electrode voltage clamp (TEVC) experiments
  • to study its effects on antinociception levels in mice
  • in PKA phosphorylation assay

Actions biochimiques/physiologiques

Protein Kinase A Inhibitor Fragment 6-22 amide (PKI 6-22) is a derivative of an active portion of the heat-stable cAMP-dependent protein kinase (PKA) inhibitor (PKI). It is a potent inhibitor of PKA.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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D B Glass et al.
The Journal of biological chemistry, 264(24), 14579-14584 (1989-08-25)
The minimal structure in the heat-stable inhibitor protein of cAMP-dependent protein kinase required for a low nanomolar potency of inhibition is the peptide Thr6-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-+ ++Ile22-NH2 (PKI-(6-22)-amide). While primary structural determinants for interaction with the protein kinase are distributed throughout the
April M Averill et al.
Journal of cellular biochemistry, 120(8), 13783-13791 (2019-04-03)
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P P Khan et al.
General and comparative endocrinology, 181, 88-97 (2012-11-24)
Possible involvement of cyclic nucleotide dependent protein kinase (PKA) and MAP kinase (MAPK) pathways during oocyte maturation in Anabas testudineus was investigated. Pre-incubation with phosphodiesterase (PDE) inhibitor, 3-isobutyl-1-methylxanthine (IBMX), inhibited 17α, 20β-DHP-induced GVBD dose dependently. PKA inhibitor, H89 could induce
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The Journal of physiology, 598(1), 139-150 (2019-10-24)
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