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P5386

Sigma-Aldrich

Poly-γ-benzyl-L-glutamate

mol wt 70,000-150,000

Synonyme(s) :

PBLG

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About This Item

Numéro CAS:
25014-27-1
Numéro MDL:
MFCD00166357
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.26

Forme

powder

Niveau de qualité

200

Poids mol.

70,000-150,000

Couleur

white to light yellow

Température de stockage

−20°C

InChI

1S/C12H15NO4/c13-10(12(15)16)6-7-11(14)17-8-9-4-2-1-3-5-9/h1-5,10H,6-8,13H2,(H,15,16)/t10-/m0/s1

Clé InChI

BGGHCRNCRWQABU-JTQLQIEISA-N

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Application


  • Hydrogen bond formation may enhance RDC-based discrimination of enantiomers.: This research explores the impact of hydrogen bond formation on residual dipolar couplings (RDC) in the discrimination of enantiomers. Poly-y-benzyl-L-glutamate (PBLG) is used as a chiral alignment medium, enhancing the sensitivity and resolution of NMR spectroscopy for enantiomeric analysis (Sager et al., 2024).

  • Potential and performance of anisotropic (19)F NMR for the enantiomeric analysis of fluorinated chiral active pharmaceutical ingredients.: This study highlights the use of PBLG as an alignment medium in anisotropic 19F NMR spectroscopy for analyzing chiral pharmaceutical compounds. The research demonstrates improved enantiomeric discrimination and quantification, crucial for pharmaceutical development (Gouilleux et al., 2024).

  • Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels.: This study investigates the self-assembly behavior of block copolymer hydrogels containing PBLG. The research shows how block sequence affects the mechanical properties and potential applications of these hydrogels in biomedical fields (Wang et al., 2024).

  • Liquid crystalline composite hydrogels with large pH-triggered anisotropic swelling for embolotherapy.: This research explores the development of liquid crystalline hydrogels incorporating PBLG for use in embolotherapy. The hydrogels demonstrate significant pH-responsive swelling, making them suitable for targeted medical applications (Zhang et al., 2024).

Remarque sur l'analyse

Molecular weight based on viscosity.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SLCK3167
SLCF5606
SLCD3653
SLBQ7365V
016K5105

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Consulter la Bibliothèque de documents

Electrospun Poly(γ-Benzyl-l-Glutamate) and Its Alkali-Treated Meshes: Their Water Wettability and Cell-Adhesion Potential.
Hakamada Y, Ohgushi N, et al.
Journal of Biomaterials Science. Polymer Edition, 28(1), 757-765 (2011)
Hua Yu Tian et al.
Biomaterials, 26(20), 4209-4217 (2005-02-03)
A novel amphiphilic biodegradable cationic hyperbranched poly(ethylene glycol)-polyethylenimine-poly(gamma-benzyl L-glutamate) (PEG-PEI-PBLG) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with PEG-PEI as a macroinitiator. PEG-PEI was firstly prepared by coupling of PEG and PEI using
Permanent polarity and piezoelectricity of electrospun α-helical poly(α-amino acid) fibers.
Dawnielle Farrar et al.
Advanced materials (Deerfield Beach, Fla.), 23(34), 3954-3958 (2011-07-29)
Thavasyappan Thambi et al.
Bioconjugate chemistry, 22(10), 1924-1931 (2011-09-09)
Poly(ethylene glycol)-b-poly(γ-benzyl L-glutamate)s bearing the disulfide bond (PEG-SS-PBLGs), which is specifically cleavable in intracellular compartments, were prepared via a facile synthetic route as a potential carrier of camptothecin (CPT). Diblock copolymers with different lengths of PBLG were synthesized by ring-opening
Supramolecular triblock copolymers controlled by the coiled-coil motif: a new tool for drug delivery.
Hana Robson Marsden et al.
Journal of controlled release : official journal of the Controlled Release Society, 148(1), e110-e111 (2011-05-03)
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Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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