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P4663

Sigma-Aldrich

Poly-L-arginine hydrochloride

mol wt 5,000-15,000

Synonyme(s) :

L-Arginine homopolymer hydrochloride

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About This Item

Numéro CAS:
26982-20-7
Numéro MDL:
MFCD00166393
Code UNSPSC :
12352209
eCl@ss :
32160406
ID de substance PubChem :
24898490
Nomenclature NACRES :
NA.26

Forme

powder

Poids mol.

5,000-15,000

Couleur

white to off-white

Application(s)

cell analysis
detection

Température de stockage

−20°C

Chaîne SMILES 

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

Clé InChI

PQEISBBDIRAKGR-LFELFHSZSA-N

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Application


  • Interfacial Electrostatics of Poly(vinylamine hydrochloride), Poly(diallyldimethylammonium chloride), Poly-L-lysine, and Poly-L-arginine Interacting with Lipid Bilayers.: This research investigates the interactions between poly-L-arginine hydrochloride and lipid bilayers, providing insights into its potential applications in drug delivery systems (McGeachy et al., 2018). (McGeachy et al., 2018).

Qualité

Contains 3% or less ornithine residue.

Remarque sur l'analyse

Molecular weight based on viscosity of precursor poly-L-ornithine.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.
Ohtake K, Maeno T, Ueda H, et al.
Pharmaceut. Res., 20, 1838-1845 (2003)
Ramsha Aamir et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Ischemic stroke is the most common type of stroke and thrombolytic therapy is the only approved treatment. However, current thrombolytic therapy with tissue plasminogen activator (tPA) is often hampered by the increased risk of hemorrhage. Plasmin, a direct fibrinolytic, has
Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.
Ohtake K, Natsume H, Ueda H, et al.
J. Controlled Release, 82, 263-275 (2002)
M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9
M Miyamoto et al.
International journal of pharmaceutics, 226(1-2), 127-138 (2001-09-05)
The effect of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of FITC-dextrans with a mean molecular weight ranging from 4.3 to 167 kDa and recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats were studied. When FITC-dextrans were co-administered intranasally
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