P4509

Palmitoyl-DL-carnitine chloride

powder

• Synonyme(s) : DL-Hexadecanoylcarnitine, Hexadecanoyl-DL-carnitine, NSC 628323, ​DL-Palmitoylcarnitine
• Formule linéaire : C₂₃H₄₆NO₄ · Cl
• Numéro CAS: 6865-14-1
• Poids moléculaire : 436.07
• Numéro MDL: MFCD00063481
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278634
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Couleur: white
• Solubilité: H₂O: 25 mg/mL (with heat or sonication)
• Température de stockage: −20°C
• Chaîne SMILES: Cl.CCCCCCCCCCCCCCCC(=O)OC(CC(O)=O)C[N](C)(C)C
• InChI: 1S/C23H46NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3,(H,25,26);1H
• Clé InChI: LGVBWSFTXDIBPB-UHFFFAOYSA-N

Description

Application

Palmitoyl-DL-carnitine chloride has been used to study its effect on inflammatory cytokines and calcium (Ca²⁺) influx, using in vitro models of prostate cancer.

Actions biochimiques/physiologiques

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells.

Palmitoyl-DL-carnitine chloride is known to inhibit biofilm formation mediated by Pseudomonas aeruginosa and Escherichia coli. It is a phosphokinase C inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)