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P1494

Sigma-Aldrich

Monoclonal Anti-PMCA4 antibody produced in mouse

~1 mg/mL, clone JA9, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Anti-Plasma Membrane Calcium ATPase 4

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About This Item

Numéro MDL:
MFCD03097151
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.44

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

JA9, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human, rat

Concentration

~1 mg/mL

Technique(s)

immunohistochemistry: suitable
indirect ELISA: 1:15,000 using human or rat tissue
western blot: 1:1,000 using human or rat tissue

Isotype

IgG1

Numéro d'accès UniProt

P23634

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ATP2B4(493)

Immunogène

purified human erythrocyte PMCA.

Forme physique

Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin and 0.05 % sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
SLCL1064
SLCL1516
SLCL0019
SLBN6414
011M1701

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

E Carafoli
Basic research in cardiology, 92 Suppl 1, 59-61 (1997-01-01)
The plasma membrane Ca-pump (134 kDa) is stimulated by calmodulin and by other treatments (exposure to acidic phospholipids, treatments with proteases, phosphorylation by protein kinases A or C, self-association to form oligomers). It is the product of four genes (in
T P Stauffer et al.
The Journal of biological chemistry, 270(20), 12184-12190 (1995-05-19)
Antibodies against the four isoforms of the human plasma membrane Ca(2+)-ATPase (PMCA) were raised using an N-terminal sequence of the pump as epitope. The antibodies against PMCA isoforms 1, 2, and 3 were not species-specific, e.g. they also recognized the
Karolina Varga et al.
Cell calcium, 55(2), 78-92 (2014-01-21)
The expression of the plasma membrane Ca2+ ATPase (PMCA) isoforms is altered in several types of cancer cells suggesting that they are involved in cancer progression. In this study we induced differentiation of MCF-7 breast cancer cells by histone deacetylase
Randa Naffa et al.
Cells, 9(5) (2020-05-18)
Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca2+ pump isoform 4b (PMCA4b or ATP2B4) as a putative metastasis suppressor in BRAF mutant melanoma cells. Metastasis suppressors are often downregulated in cancer
Ling Wang et al.
PloS one, 10(4), e0122932-e0122932 (2015-04-24)
An increased risk for developing essential hypertension, stroke and diabetes is associated with single nucleotide gene polymorphisms in renalase, a newly described secreted flavoprotein with oxidoreductase activity. Gene deletion causes hypertension, and aggravates acute ischemic kidney (AKI) and cardiac injury.

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