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P0874

Sigma-Aldrich

Anti-Potassium Channel KIR6.1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-KATP Inward Rectifier K+ Channel 4, Anti-KCNJ8

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About This Item

Numéro MDL:
MFCD08705505
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

rat

Technique(s)

western blot: 1:200 using rat heart membranes

Numéro d'accès UniProt

Q63664

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... KCNJ8(3764)
mouse ... Kcnj8(16523)
rat ... Kcnj8(25472)

Spécificité

Specific for KIR6.1; does not cross react with KIR6.2.

Immunogène

peptide, (C)KRNSMRRNNSMRRSN, corresponding to amino acid residues 382-396 of rat KIR6.1. This sequence has 15/16 residues identical in human, pig, rabbit, and mouse.

Forme physique

Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

William C Cole et al.
Journal of cardiovascular electrophysiology, 14(1), 94-103 (2003-03-11)
ATP-sensitive potassium channels (K(ATP)) of vascular smooth muscle cells represent potential therapeutic targets for control of abnormal vascular contractility. The biophysical properties, regulation and pharmacology of these channels have received intense scrutiny during the past twenty years, however, the molecular
T Baukrowitz et al.
European journal of biochemistry, 267(19), 5842-5848 (2000-09-21)
The KATP channel is a heterooctamer composed of two different subunits, four inwardly rectifying K+ channel subunits, either Kir6. 1 or Kir6.2, and four sulfonylurea receptors (SUR), which belong to the family of ABC transporters. This unusual molecular architecture is
Mangala M Soundarapandian et al.
Journal of neurochemistry, 103(5), 1982-1988 (2007-09-22)
The Kir6.1 channels are a subtype of ATP-sensitive inwardly rectifying potassium (K(ATP)) channels that play an essential role in coupling the cell's metabolic events to electrical activity. In this study, we show that functional Kir6.1 channels are located at excitatory
Yang Yang et al.
The Journal of biological chemistry, 286(11), 9298-9307 (2011-01-11)
The vascular ATP-sensitive K(+) (K(ATP)) channel is targeted by a variety of vasoactive substances, playing an important role in vascular tone regulation. Our recent studies indicate that the vascular K(ATP) channel is inhibited in oxidative stress via S-glutathionylation. Here we
Maria Consiglia Trotta et al.
Frontiers in physiology, 9, 1475-1475 (2018-11-13)
The study explored the anti-hypertrophic effect of the melanocortin MC5R stimulation in H9c2 cardiac myocytes exposed to high glucose. This has been done by using α-MSH and selective MC5R agonists and assessing the expression of GLUT4 and GLUT1 transporters, miR-133

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