P0547

Pentamidine isethionate salt

powder

• Synonyme(s) : 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt), 4,4′-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate)
• Formule linéaire : CH₂[CH₂CH₂OC₆H₄C(=NH)NH₂]₂·2HOCH₂CH₂SO₃H
• Numéro CAS: 140-64-7
• Poids moléculaire : 592.68
• Numéro CE : 205-424-1
• Numéro MDL: MFCD00079213
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277999
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Pf: 188-194 °C (lit.)
• Spectre d'activité de l'antibiotique: fungi
• Mode d’action: enzyme | inhibits
• Auteur: Celgene
• Température de stockage: −20°C
• Chaîne SMILES: OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
• InChI: 1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)
• Clé InChI: YBVNFKZSMZGRAD-UHFFFAOYSA-N
• Informations sur le gène: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907) , NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

Description

Application

Antimicrobial against Pneumocystis carinii.

Pentamidine isethionate salt has been used:

• as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays
• as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K⁺ channel trafficking
• as an anti-leishmanial agent in promastigotes

Actions biochimiques/physiologiques

Neuroprotective; inhibits constitutive nitric oxide synthase in the brain; NMDA glutamate receptor antagonist.

Pentamidine isethionate is used as a second line drug for leishmaniasis.

Caractéristiques et avantages

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H317,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3