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Key Documents

N8159

Sigma-Aldrich

Albumin, Nitrated from bovine serum

lyophilized powder

Synonyme(s) :

Nitrated BSA

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.41

Source biologique

bovine

Niveau de qualité

Forme

lyophilized powder

Technique(s)

immunoblotting: suitable

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

bovine ... ALB(280717)

Description générale

Albumin, Nitrated (Nitrated BSA), is prepared by chemical modification of bovine serum albumin (BSA) by peroxynitrite. Peroxynitrite (ONOO-), a potent oxidant is an important member of the family of reactive oxygen and nitrogen species.

Application

Positive control in immunoblotting assays for Anti-Nitrotyrosine (Sigma Product Number N 0409).

Actions biochimiques/physiologiques

Peroxynitrite promotes the nitration of tyrosine residues in proteins linked, oxidation of redox metal centers, DNA, lipids and nitrosation of cysteine residues in proteins, suggesting that peroxynitrite plays a major role in oxidative cellular damage. Peroxynitrite has been implicated in the pathogenesis of several inflammatory, infectious and degenerative human disease. These include neurological conditions such as Alzheimer′s disease, amyotrophic lateral sclerosis (ALS), the pathogenesis of asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury.

Forme physique

Lyophilized from 0.01 M phosphate buffered saline, pH 7.4

Notes préparatoires

Bovine serum albumin (BSA) nitrated with peroxynitrite.

Remarque sur l'analyse

Does not contain sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation
Lai H and Yen GC
Bioscience, Biotechnology, and Biochemistry, 66(1), 22-28 (2002)
The Intracellular Redox Stress Caused by Hexavalent Chromium is Selective for Proteins that Have Key Roles in Cell Survival and Thiol Redox Control
Judith M
Toxicology (2011)
Nitric oxide and peroxynitrite in health and disease
Pacher P, et al.
Physiological Reviews, 87(1), 315-424 (2007)
Péter Borbély et al.
Antioxidants (Basel, Switzerland), 10(1) (2021-01-13)
Selenium (Se) enrichment of Stevia rebaudiana Bertoni can serve a dual purpose, on the one hand to increase plant biomass and stress tolerance and on the other hand to produce Se fortified plant-based food. Foliar Se spraying (0, 6, 8

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