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N5413

Sigma-Aldrich

Anti-Nestin antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-FJ21841, Anti-NES, Anti-Nbla00170

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About This Item

Numéro MDL:
MFCD03455626
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~110 kDa (cleaved)
antigen ~177 kDa
antigen ~270 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

Numéro d'accès UniProt

P48681

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NES(10763)
mouse ... Nes(18008)
rat ... Nes(25491)

Description générale

Nestin (NES) is a class VI cytoplasmic protein. It is expressed in the intermediate filaments and has a molecular weight of 177kDa. The gene encoding it is localized on human chromosome 1q23.1 with four exons.

Immunogène

synthetic peptide corresponding to residues 254-270 of human Nestin. This sequence is 93% identical in rat.

Actions biochimiques/physiologiques

Nestin (NES) functions as a regulator of proteins which are involved in cell growth. It also interacts with other proteins of the intermediate filament. NES has been studied as a marker of neural stem cells.

Forme physique

solution in phosphate buffered saline, containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Y Chen et al.
Osteoarthritis and cartilage, 23(10), 1728-1735 (2015-06-02)
Osteoarthritis (OA) is a progressive joint disorder. To date, there is not effective medical therapy. Joint distraction has given us hope for slowing down the OA progression. In this study, we investigated the benefits of joint distraction in OA rat
Nianping Zhang et al.
International journal of molecular medicine, 40(3), 814-824 (2017-07-18)
Pluripotent stem cells (PSCs) are regarded as potential sources that provide specific neural cells for cell therapy in some nervous system diseases. However, the mechanisms underlying the neural differentiation of PSCs remain largely unknown. MicroRNAs (miRNAs or miRs) are a class of
Mohamed Ahmed Eladl et al.
International journal of nephrology and renovascular disease, 10, 61-76 (2017-03-07)
Several renal disorders affect the glomerular podocytes. Compensatory structural and functional changes have been observed in animals that have undergone unilateral renal ablation. These changes occur as a pliant response to quench the increased functional demand to maintain homeostasis of
Chhagan Bihari et al.
Hepatology (Baltimore, Md.), 64(4), 1273-1288 (2016-08-04)
Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients. We
Wei Zhao et al.
Scientific reports, 6, 21176-21176 (2016-02-18)
Restenosis or occlusion after vascular procedures is ascribed to intimal hyperplasia. Transforming growth factor (TGF)-β1 is involved in recruitment of mesenchymal stem cells (MSCs) following arterial injury, and its release from latent TGF-binding protein by matrix metalloproteinase (MMP)-14-induced proteolysis contributes
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