N0267

(±)-Nicotine

≥99% (TLC), liquid

• Formule empirique (notation de Hill): C₁₀H₁₄N₂
• Numéro CAS: 22083-74-5
• Poids moléculaire : 162.23
• Beilstein: 82108
• Numéro MDL: MFCD00065370
• Code UNSPSC : 12352210
• eCl@ss : 39151701
• ID de substance PubChem : 24897418
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥99% (TLC)
• Forme: liquid
• Activité optique: [α]25/D 0°(lit.)
• Couleur: yellow
• Solubilité: ethanol: 50 mg/mL
• Densité: 1.02 g/mL at 25 °C (lit.)
• Chaîne SMILES: CN1CCCC1c2cccnc2
• InChI: 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
• Clé InChI: SNICXCGAKADSCV-UHFFFAOYSA-N
• Informations sur le gène: human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) ; rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)

Description

Application

(±)-Nicotine has been used:

• as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
• as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
• as a test compound to study its effects on fibril formation

Actions biochimiques/physiologiques

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

Prototype nicotinic acetylcholine receptor agonist.

Conditionnement

The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS05,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H310 + H330,H315,H318,H411
• Conseils de prudence: P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 213.8 °F - closed cup
• Point d'éclair (°C): 101 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter