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M7068

Sigma-Aldrich

MPP dihydrochloride hydrate

≥97% (HPLC), powder, estrogen receptor α agonist

Synonyme(s) :

1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate, Methyl-piperidino-pyrazole hydrate

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About This Item

Formule empirique (notation de Hill):
C29H31N3O3 · 2 HCl · xH2O
Numéro CAS:
911295-24-4
Poids moléculaire :
542.50 (anhydrous basis)
Numéro MDL:
MFCD06411603
Code UNSPSC :
51111800
ID de substance PubChem :
24724540
Nomenclature NACRES :
NA.77

product name

MPP dihydrochloride hydrate, ≥97% (HPLC), white, powder

Pureté

≥97% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white

Solubilité

DMSO: soluble ≥20 mg/mL

Chaîne SMILES 

Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5

InChI

1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H

Clé InChI

FWDNPWVVRVSJQH-UHFFFAOYSA-N

Description générale

Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.

Application

MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:
  • in human breast cancer MCF-7 cells
  • to pre-treat endometrial ex vivo organ cultures (EVOCs)
  • to treat pituitary glands to monitor luteinizing hormone secretion

Actions biochimiques/physiologiques

MPP dihydrochloride is a specific estrogen receptor α antagonist.
Methyl-piperidino-pyrazole hydrate (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β. It promotes silibinin induced apoptosis in human breast cancer MCF-7 cells.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Methyl-piperidino-pyrazole (MPP), an estrogen receptor alpha (ERalpha)-selective antagonist we developed, has a basic side chain (BSC) attached to an ERalpha-selective agonist ligand, methyl-pyrazole-triol (MPT) through an ether linkage. To remove the possibility that metabolic cleavage of the BSC in MPP
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Estrogen is well known to have a modulatory role on gastrointestinal tract, particularly through its interaction with nuclear estrogen receptors (ERs), alpha and beta (ERα/β). Recent functional studies also indicate that estrogen can activate a G-protein coupled estrogen receptor, GPR30
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