M6383

2-Methoxyestradiol

powder

• Synonyme(s) : 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
• Formule empirique (notation de Hill): C₁₉H₂₆O₃
• Numéro CAS: 362-07-2
• Poids moléculaire : 302.41
• Numéro MDL: MFCD00010489
• Code UNSPSC : 51111800
• ID de substance PubChem : 24278561
• Nomenclature NACRES : NA.77

Propriétés

• Stérilité: non-sterile
• Niveau de qualité: 200
• Pureté: ≥98% (HPLC); ≥98% (TLC)
• Forme: powder
• Couleur: white to faint yellow
• Pf: 189-190 °C
• Solubilité: DMSO: 10 mg/mL; ethanol: 10 mg/mL; H₂O: insoluble
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: OC1=C(C=C(C2=C1)[C@]3([H])[C@](CC2)([H])[C@]4([H])CC[C@H](O)[C@](C)4CC3)OC
• InChI: 1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
• Clé InChI: CQOQDQWUFQDJMK-SSTWWWIQSA-N
• Informations sur le gène: human ... ESR1(2099) , ESR2(2100)

Description

Description générale

2-Methoxyestradiol (2-ME) is a metabolite, derived from estradiol. It is usually seen at high levels in the normal follicle.

Application

2-Methoxyestradiol has been used:

• as hypoxia-inducible factor 1-alpha (HIF-1α) inhibitor to treat microglia to test whether hypoxia leads to cell death
• to determine the anticancer potential in L-lactate-activated osteosarcoma cells
• as a reference chemical and angiogenesis inhibitor to assess the performance of in vitro angiogenesis assay

Actions biochimiques/physiologiques

2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis.It has little affinity for classical estrogen receptors.

2-Methoxyestradiol plays a key role in the apoptosis of tumor cells. It also participates in microtubule stabilization. It exhibits cardioprotective activity and acts as an anticancer agent.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H301 + H311 + H331,H315,H319,H335,H350,H360,H372,H410
• Conseils de prudence: P273 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges