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M2521

Sigma-Aldrich

IgM, Lambda from murine myeloma

clone MOPC 104E, ascites fluid, lyophilized powder

Synonyme(s) :

Mouse IgM-λ

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About This Item

Numéro MDL:
MFCD00164805
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Clone

MOPC 104E, monoclonal

Forme

lyophilized powder

Température de stockage

2-8°C

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Description générale

The MOPC-104E tumor line that produces mouse IgM is a mineral oil induced plasmacytoma originated and carried intraperitoneally in BALB/c mice. Mouse consists of five immunoglobulin classes- IgM, IgG, IgA, IgD and IgE. IgM is present on the surface of B lymphocytes in its monomeric form.

Spécificité

Antigen Specificity: α(1→3) glucose

Application

IgM, λ from murine myeloma has been used as control in chromatin immunoprecipitation analysis. It has also been used in immunohistochemitsry.
IgM, λ from murine myeloma was used as a control antibody in ChIP analysis of GATA-1-null and GATA-1-positive G1E cells.

Actions biochimiques/physiologiques

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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GATA-1-mediated Transcriptional Repression Yields Persistent Transcription Factor IIB-Chromatin Complexes
Martowicz ML, et al.
The Journal of biological chemistry, 281(49), 37345-37352 (2006)
The Immunoglobulins: Structure and Function (1998)
Endosomal/Lysosomal Processing of Gangliosides Affects Neuronal Cholesterol Sequestration in Niemann-Pick Disease Type C
Zhou S, et al.
The American Journal of Pathology, 179(2), 890-902 (2011)
Robert McGlynn et al.
The Journal of comparative neurology, 480(4), 415-426 (2004-11-24)
The mucopolysaccharidoses (MPSs) are a complex family of lysosomal storage disorders characterized by failure to degrade heparan sulfate (HS) and/or other types of glycosaminoglycans (GAGs) secondary to the absence of specific lysosomal enzymes. An accompanying storage of glycosphingolipids (GSLs), most
Melissa L Martowicz et al.
The Journal of biological chemistry, 281(49), 37345-37352 (2006-09-12)
The hematopoietic GATA factors GATA-1 and GATA-2, which have distinct and overlapping roles to regulate blood cell development, are reciprocally expressed during erythropoiesis. GATA-1 directly represses Gata2 transcription, and reduced GATA-2 synthesis promotes red blood cell development. Gata2 repression involves
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