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M1323

Sigma-Aldrich

Midostaurin hydrate

≥98% (HPLC), solid, kinase inhibitor

Synonyme(s) :

CGP 41251, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide, N-benzoylstaurosporine, PKC-412

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About This Item

Formule empirique (notation de Hill):
C35H30N4O4 · xH2O
Numéro CAS:
1217450-80-0
Poids moléculaire :
570.64 (anhydrous basis)
Numéro MDL:
MFCD12828879
Code UNSPSC :
12352200
ID de substance PubChem :
329817870
Nomenclature NACRES :
NA.77

product name

Midostaurin hydrate, ≥98% (HPLC), solid

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Couleur

off-white

Solubilité

DMSO: >10 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

O.CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)[n@@H]3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8[n@H]2c7c35)N(C)C(=O)c9ccccc9

InChI

1S/C35H30N4O4.H2O/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38;/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40);1H2/t25-,26-,32-,35+;/m1./s1

Clé InChI

YEKDLUZCCDJYAJ-LJAYRLSQSA-N

Actions biochimiques/physiologiques

Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. Midostaurin is a potent inhibitor of a spectrum of FLT3 activation loop mutations.

Caractéristiques et avantages

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H360FD

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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