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L1663

Sigma-Aldrich

Lidocaine N-ethyl chloride

Synonyme(s) :

N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium chloride

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About This Item

Formule empirique (notation de Hill):
C16H27N2OCl
Numéro CAS:
5369-03-9
Poids moléculaire :
298.85
Numéro MDL:
MFCD01669894
Code UNSPSC :
12352200
ID de substance PubChem :
24896288
Nomenclature NACRES :
NA.77

Conditions de stockage

protect from light

Niveau de qualité

100

Solubilité

H2O: soluble

Température de stockage

room temp

Chaîne SMILES 

[Cl-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

Clé InChI

LLPPOMUAOGMYQI-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

Autres remarques

Stable at room temperature lyophilized. In solution, store at 4 °C for up to two weeks. Store solutions at -20 °C for up to six months.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Vijay K Samineni et al.
Nature communications, 10(1), 4356-4356 (2019-09-27)
Itch is a distinct aversive sensation that elicits a strong urge to scratch. Despite recent advances in our understanding of the peripheral basis of itch, we know very little regarding how central neural circuits modulate acute and chronic itch processing.
Mariana Colino-Oliveira et al.
Purinergic signalling, 12(2), 283-294 (2016-02-22)
Brain-derived neurotrophic factor (BDNF) and adenosine are widely recognized as neuromodulators of glutamatergic transmission in the adult brain. Most BDNF actions upon excitatory plasticity phenomena are under control of adenosine A2A receptors (A2ARs). Concerning gamma-aminobutyric acid (GABA)-mediated transmission, the available
Michael A Freed
The Journal of physiology, 595(22), 6979-6991 (2017-09-16)
Bipolar and amacrine cells presynaptic to the ON sustained α cell of mouse retina provide currents with a higher signal-to-noise power ratio (SNR) than those presynaptic to the OFF sustained α cell. Yet the ON cell loses proportionately more SNR
Iina Korkka et al.
Stem cells translational medicine, 8(2), 179-193 (2018-11-06)
Retinal pigment epithelium (RPE) performs important functions for the maintenance of photoreceptors and vision. Malfunctions within the RPE are implicated in several retinal diseases for which transplantations of stem cell-derived RPE are promising treatment options. Their success, however, is largely
Daniel Müller-Komorowska et al.
Frontiers in neural circuits, 14, 16-16 (2020-05-13)
Transgenic Cre-recombinase expressing mouse lines are widely used to express fluorescent proteins and opto-/chemogenetic actuators, making them a cornerstone of modern neuroscience. The investigation of interneurons in particular has benefitted from the ability to genetically target specific cell types. However
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