I7034
Monoclonal Anti-Interleukin-4 antibody produced in mouse
clone 3007, purified immunoglobulin, lyophilized powder
Synonyme(s) :
Anti-IL-4
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About This Item
Produits recommandés
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
3007, monoclonal
Forme
lyophilized powder
Espèces réactives
human
Technique(s)
immunohistochemistry: 5-15.0 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL
Isotype
IgG1
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... IL4(3565)
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Description générale
Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 specifically recognizes human interleukin-4 (12-20 kDa). It does not react with mouse IL-4.
Anti-Interleukin-4 specifically recognizes human interleukin-4 (12-20 kDa). It does not react with mouse IL-4.
Immunogène
purified, E. coli-derived recombinant human interleukin-4.
Application
Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For immunohistochemistry, a working concentration of 15 μg/ml may be used for human tissues and 5-15 μg/ml may be used for human cells. The antibody is suitable for neutralization reactions.
Forme physique
Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Barbara Świerczek-Lasek et al.
International journal of molecular sciences, 20(16) (2019-08-16)
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M Stein et al.
The Journal of experimental medicine, 176(1), 287-292 (1992-07-01)
Expression of the macrophage mannose receptor is inhibited by interferon gamma (IFN-gamma), a T helper type 1 (Th-1)-derived lymphokine. Interleukin 4 (IL-4), a Th-2 lymphocyte product, upregulates major histocompatibility class II antigen expression but inhibits inflammatory cytokine production by macrophages.
Alberto Mantovani et al.
Trends in immunology, 25(12), 677-686 (2004-11-09)
Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests
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C K Oh et al.
European respiratory review : an official journal of the European Respiratory Society, 19(115), 46-54 (2010-10-20)
Asthma is a complex, persistent, inflammatory disease characterised by airway hyperresponsiveness in association with airway inflammation. Studies suggest that regular use of high-dose inhaled corticosteroids and long-acting bronchodilators or omalizumab (a humanised monoclonal antibody that binds to immunoglobulin E and
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