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Key Documents

I5270

Sigma-Aldrich

Anti-Interleukin-11 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonyme(s) :

Anti-IL-11

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About This Item

Numéro MDL:
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

human

Technique(s)

neutralization: suitable

Numéro d'accès UniProt

Température de stockage

−20°C

Informations sur le gène

human ... IL11(3589)

Description générale

Interleukin-11 (IL-11) is a pleotropic cytokine that belongs to the IL-6 family. The effects of IL-11 include hemopoiesis, macrophage differentiation and thrombopoiesis. Many cell types including osteoblasts, trophoblasts, fibroblasts, chondrocytes and a variety of tissue such as brain, gut, spinal cord and testis secrete IL-11. The cellular effects of IL-11 are mediated by a multimeric complex consisting of IL-11Rα and gp130Rβ subunits. The pathways activated by IL-11 include JAK/STAT, Ras/MAPK and Grb2 signaling. IL-11 plays a major role in inflammatory responses, immune responses by regulating the production of IgG by B cells and in tumorigenesis-related inflammation
Anti-Interleukin-11 antibody specifically reacts with human IL-11.

Spécificité

The antibody neutralizes the biological activity of recombinant human IL-11.

Immunogène

recombinant human IL-11 expressed in Sf 21 insect cells.

Application

Anti-Human IL-11 is suitable for neutralization reactions.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Notes préparatoires

Purified using protein G.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

G Trinchieri et al.
Progress in growth factor research, 4(4), 355-368 (1992-01-01)
Natural Killer cell Stimulatory Factor (NKSF) or interleukin-12 (IL-12) is a heterodimeric cytokine of 70 kDa formed by a heavy chain of 40 kDa (p40) and a light chain of 35 kDa (p35). Although it was originally identified and purified
M Kobayashi et al.
The Journal of experimental medicine, 170(3), 827-845 (1989-09-01)
We have identified and purified a novel cytokine, NK cell stimulatory factor (NKSF), from the cell-free supernatant fluid of the phorbol diester-induced EBV-transformed human B lymphoblastoid cell line RPMI 8866. NKSF activity is mostly associated to a 70-kD anionic glycoprotein.
D S Schoenhaut et al.
Journal of immunology (Baltimore, Md. : 1950), 148(11), 3433-3440 (1992-06-01)
Human IL-12 (NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that can act as a growth factor for activated human T and NK cells, enhance the lytic activity of human NK/lymphokine-activated killer cells, and stimulate the
A S Stern et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(17), 6808-6812 (1990-09-01)
A cytokine that can synergize with interleukin 2 to activate cytotoxic lymphocytes was purified to homogeneity. The protein, provisionally called cytotoxic lymphocyte maturation factor (CLMF), was isolated from a human B-lymphoblastoid cell line that was induced to secrete lymphokines by

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