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I2644

Sigma-Aldrich

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

IL-2, hIL-2, Interleukin-2, T-cell growth factor

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About This Item

Numéro MDL:
MFCD00165721
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in E. coli

Forme

lyophilized powder

Puissance

≤700 EC50

Qualité

endotoxin tested

Poids mol.

15.5 kDa

Conditionnement

pkg of 5X10 μg
pkg of 10 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

≤1 EU/μg

Numéro d'accès UniProt

P60568

Température de stockage

−20°C

Informations sur le gène

human ... IL2(3558)

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Catégories apparentées

Description générale

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.

Application

Interleukin-2 human has been used:
  • in the stimulation of natural killer cells
  • to study its ability to stimulate lymphocyte growth and prevent apoptosis
  • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus

Actions biochimiques/physiologiques

Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Forme physique

Lyophilized, 0.2 μm filtered, no additives.

Remarque sur l'analyse

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Loss of immune tolerance to IL-2 in type 1 diabetes
Perol L, et al.
Nature Communications, 7(2), 13027-13027 (2016)
Stefania Braidotti et al.
Frontiers in bioscience (Landmark edition), 27(2), 39-39 (2022-03-01)
The T-cell engager antibody blinatumomab (BlincytoT⁢M) represents a promising rescue therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab creates a tight synapsis between CD3+ T-lymphocytes and leukemic CD19+ B-cells
Interleukin 2, 37-37 (2012)
Culture methods for turtle lymphocytes
Ulsh BA, et al.
Methods in Cell Science : An Official Journal of the Society for In Vitro Biology, 22(4), 285-297 (2000)
Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype
Pridgeon C, et al.
Rheumatology (Basel), 42(7), 870-878 (2003)
Afficher tous les articles scientifiques apparentés

Articles

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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