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I2282

Anti-Insulin-Like Growth Factor-II antibody produced in goat

Name: Anti-Insulin-Like Growth Factor-II antibody produced in goat
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-IGF-II

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About This Item

Numéro MDL:

MFCD00162567

Code UNSPSC :

51111800

Nomenclature NACRES :

NA.41

Source biologique

goat

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse

Technique(s)

indirect ELISA: 0.5-1.0 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL

Numéro d'accès UniProt

P09535

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Igf2(16002)

Description générale

Insulin-like growth factor II (IGF II) also refers as multiplication stimulating activity or MSA is a protein that is structurally similar to proinsulin. It is a potent mitogen for many cultured cells like mouse 3T3 cells, normal rat kidney cells, human or chicken fibroblasts and MCF-7 human breast carcinoma cells. IGF II possess mitogenic growth factor property and hence facilitates growth-promoting activity in embryonic development. Anti-Insulin-Like Growth Factor-II antibody can be used for neutralization assays. Goat anti-Insulin-Like Growth Factor-II antibody reacts specifically with recombinant mouse IGF-II. The product has also shown 25% (approx.) cross-reactivity with recombinant human IGF-II.

Immunogène

purified recombinant mouse insulin-like growth factor II, expressed in E. coli.

Application

Anti-Insulin-Like Growth Factor-II antibody can be used in ELISA and western blotting.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit

Description

Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Activation of endoproteolytic processing of insulin-like growth factor-II in fetal, early postnatal, and pregnant rats and persistence of circulating levels in postnatal life.

Qing Qiu et al.

Endocrinology, 148(10), 4803-4811 (2007-07-14)

The process of posttranslational modifications of IGF-II likely has important physiological consequences. In addition to mature IGF-II, glycosylated proIGF-II(156-amino acid peptide) and two glycosylated big IGF-II forms, IGF-II(1-104) and IGF-II(1-87), have been identified in the human circulation. Due to lack

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

K P Karey et al.

Cancer research, 48(14), 4083-4092 (1988-07-15)

A completely serum-free assay method has been used to compare the mitogenic activities of polypeptide growth factors and estrogens with MCF-7 and T47D human breast cancer cells in culture. The lines were maintained in a viable, slowly dividing condition in

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