I0404

Indirubin-3′-oxime

≥98% (HPLC), solid

• Synonyme(s) : Indirubin-3′-monoxime
• Formule empirique (notation de Hill): C₁₆H₁₁N₃O₂
• Numéro CAS: 160807-49-8
• Poids moléculaire : 277.28
• Numéro MDL: MFCD02683594
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278483
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Poids mol.: 277.28
• Solubilité: DMSO: >10 mg/mL; H₂O: insoluble
• Température de stockage: room temp
• Chaîne SMILES: O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4ccccc34
• InChI: 1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+
• Clé InChI: HBDSHCUSXQATPO-BGBJRWHRSA-N

Description

Application

Indirubin-3′-oxime has been used in the inhibition of glycogen synthase kinase 3 in human monocytic cell line, THP-1.

Actions biochimiques/physiologiques

Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.

Indirubin-3′-oxime mediates apoptosis in Jurkat T cells and has anti-tumor functionality. Indirubin-3′-oxime inhibits Y box binding protein 1 (YB1) translocation, contributing to anticancer functionality. Indirubin-3′-oxime decreases expression of estrogen-related receptor γ (ERRγ) and peroxisome proliferator-activated receptor-γ co-activator-1α (PGC1α) in human neuroblastoma, leading to cell cycle arrest and mitochondrial dysfunction.

Caractéristiques et avantages

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)