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H7654

Sigma-Aldrich

Hydroxyguanidine sulfate salt

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About This Item

Formule linéaire :
CH5N3O · 1/2H2SO4
Numéro CAS:
6345-29-5
Poids moléculaire :
124.11
Numéro CE :
228-749-0
Numéro MDL:
MFCD00042033
Code UNSPSC :
12352202
ID de substance PubChem :
329815245
Nomenclature NACRES :
NA.77

Source biologique

synthetic (organic)

Pureté

≥98% (TLC)

Forme

powder

Solubilité

water: 25 mg/mL, clear, colorless

Température de stockage

2-8°C

Chaîne SMILES 

NC(=N)NO.NC(=N)NO.OS(O)(=O)=O

InChI

1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)

Clé InChI

MTGDDPZRXSDPFH-UHFFFAOYSA-N

Actions biochimiques/physiologiques

An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals. Reacts with NO to form an adduct which is a potent and stable vasodilator.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Rémy Ricoux et al.
European journal of biochemistry, 270(1), 47-55 (2002-12-21)
Nitric oxide (NO) is a potent intra- and intercellular messenger involved in the control of vascular tone, neuronal signalling and host response to infection. In mammals, NO is synthesized by oxidation of l-arginine catalysed by hemeproteins called NO-synthases with intermediate
Ming Xian et al.
Bioorganic & medicinal chemistry, 10(9), 3049-3055 (2002-07-12)
Enzymatic generation of nitric oxide (NO) by nitric oxide synthase (NOS) consists of two oxidation steps. The first step converts L-arginine to N(G)-hydroxy-L-arginine (NOHA), a key intermediate, and the second step converts NOHA to NO and L-citrulline. To fully probe
Tingwei Cai et al.
Bioorganic & medicinal chemistry letters, 12(11), 1507-1510 (2002-05-29)
The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile
David Lefèvre-Groboillot et al.
Biochemistry, 42(13), 3858-3867 (2003-04-02)
The interaction of various N-alkyl- and N-aryl-N'-hydroxyguanidines with recombinant NOS containing or not containing tetrahydrobiopterin (BH(4)) was studied by visible, electronic paramagnetic resonance (EPR), and resonance Raman (RR) spectroscopy. N-Hydroxyguanidines interact with the oxygenase domain of BH(4)-free inducible NOS (BH(4)-free
S A Everett et al.
Free radical biology & medicine, 24(1), 1-10 (1998-01-22)
The oxidative denitrification of the antitumour agent hydroxyguanidine (HOG) has been investigated by radiolysis methods and EPR spectroscopy. The azide radical (N3.), a model one-electron oxidant, reacts with HOG with the rate constant 5.1 x 10(9) dm3 mol(-1) s(-1) to
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