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Autres documents

GW22778

Sigma-Aldrich

Anti-GSK3a antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

rat, mouse, human

Fabricant/nom de marque

Genway 15-288-22778

Technique(s)

indirect ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

NP_063937.1

Numéro d'accès UniProt

P49840

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GSK3A(2931)

Immunogène

Immunogen Sequence: GI # 11995474, sequence 89-100
Synthetic peptide sequence of glycogen synthase kinase 3α.

Application

Anti-GSK3α antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Glycogen synthase kinase-3α is an enzyme encoded by the GSK3A gene in humans and is located on chromosome 19q13.2. It is a serine-threonine kinase that exists as two isoforms, α and β. GSK-3α is widely expressed throughout the follicles and plays a role in cancer development such as acute myeloid leukemia (AML). It is an important component of the therapeutic actions of drugs used to treat mood disorders and can be a potential target for developing new therapeutic interventions.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

P C Shaw et al.
Genome, 41(5), 720-727 (1998-11-11)
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase that exists as two isoforms, alpha and beta, encoded by separate genes. Phosphorylation targets include a variety of cytoplasmic and nuclear proteins. Recent studies found that neurofilaments, amyloid precursor protein, and tau
Xiaohua Li et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(11), 2143-2154 (2010-07-30)
Little is known regarding the mechanisms underlying the complex etiology of mood disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 discovery that lithium inhibits glycogen synthase kinase-3 (GSK3) raised the possibility that impaired inhibition of GSK3
Versha Banerji et al.
The Journal of clinical investigation, 122(3), 935-947 (2012-02-14)
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long-term survival of patients with AML has changed little over the past decade, necessitating the identification and validation of new AML targets. Integration of genomic approaches
Koichi Yamauchi et al.
Archives of dermatological research, 302(4), 263-270 (2009-08-26)
Beta-catenin is involved in the hair follicle morphogenesis and stem cell differentiation, and inhibition of glycogen synthase kinase-3 (GSK-3) increases beta-catenin concentration in the cytoplasm. To examine the effects of GSK-3 inhibition on the hair follicle epithelium, we first examined

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